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American Society of Microbiology ABMM Sample Questions:

1. A patient with a history of travel to a rural area develops a febrile illness with jaundice and dark urine.
Peripheral blood smear reveals intraerythrocytic parasites with a characteristic Maltese cross morphology.
The MOST likely causative agent is:

A) Plasmodium falciparum
B) Trypanosoma brucei
C) Plasmodium vivax
D) Babesia microti

2. A 6-year-old child presents with a pharyngitis characterized by a grayish-white pseudomembrane covering the tonsils and posterior pharynx. Gram stain of the membrane reveals Gram-positive bacilli. Culture on Loeffler's medium shows growth of metachromatic granules. The MOST significant virulence factor associated with this organism's pathogenicity is:

A) Streptolysin O
B) Diphtheria toxin
C) Hyaluronidase
D) Protein A

3. Clavulanic acid is often combined with amoxicillin (e.g., Augmentin™) to overcome certain types of bacterial resistance. What is the primary mechanism by which clavulanic acid enhances amoxicillin's activity?

A) It increases the outer membrane permeability to amoxicillin in Gram-negative bacteria.
B) It binds to alternative penicillin-binding proteins (PBPs), providing a synergistic bactericidal effect.
C) It functions as a potent, irreversible inhibitor of many bacterial beta-lactamase enzymes.
D) It inhibits bacterial efflux pumps that would otherwise remove amoxicillin from the cell.

4. Which of the following bacterial genera inherently possesses D-alanyl-D-lactate peptide subunits in its peptidoglycan precursors, conferring natural, high-level resistance to vancomycin?

A) Staphylococcus
B) Leuconostoc
C) Enterococcus (e.g., E. gallinarum, E. casseliflavus carrying vanC)
D) Streptococcus

5. A patient with a history of chronic sinusitis develops a severe invasive fungal infection involving the nasal sinuses and extending into the orbit. Tissue biopsy reveals broad, aseptate hyphae with irregular branching.
The patient is diabetic and acidotic. The MOST likely causative organism belongs to the genus:

A) Aspergillus
B) Mucor or Rhizopus
C) Scedosporium
D) Fusarium

Solutions: